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      Association of RNF43 with cell cycle proteins involved in p53 pathway.

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          Abstract

          Our previous study has demonstrated that RNF43 could regulate the cell cycle in a p53-dependent manner in HCC. In this study, we aimed to access whether RNF43 could interact with cell cycle proteins involved in p53 pathway, including pRB, Cyclin D1 and MDM2. Totally, 123 paired HCC tissues and corresponding noncancerous tissues from HCC patients were included, and the expression of Cyclin D1, pRB and MDM2 was analyzed using tissue microarray. Our results showed the expression level of RNF43 in HCC was positively correlated with that of MDM2, Cyclin D1 and pRB-S780. There was no significant correlation between the expression of RNF43 and pRB-S807/S811. Indicating that RNF43 effected cell cycling by regulating the expression of pRB, Cyclin D1 and MDM2 proteins, and pRB-S780 but not pRB-S807/S811, was participated in RNF43 regulated cell cycling.

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          Author and article information

          Journal
          International journal of clinical and experimental pathology
          1936-2625
          1936-2625
          2015
          : 8
          : 11
          Affiliations
          [1 ] Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public HealthHangzhou, China; Key Laboratory of Organ Transplantation, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of MedicineHangzhou, China.
          [2 ] Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health Hangzhou, China.
          Article
          4713620
          26823834
          6b3828b5-c2d8-45a8-84da-26a9cc922252
          History

          HCC,cell cycling,p53,tissue microarray,RNF43
          HCC, cell cycling, p53, tissue microarray, RNF43

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