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      Butylated hydroxytoluene and N-acetylcysteine attenuates tumor necrosis factor-alpha (TNF-alpha) secretion and TNF-alpha mRNA expression in alveolar macrophages from human lung transplant recipients in vitro.

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          Abstract

          Tumor necrosis factor-alpha (TNF-alpha) is a polypeptide cytokine principally produced by macrophages/monocytes and commonly associated with inflammatory conditions. The present study was designed to investigate whether the antioxidants butylated hydroxytoluene (BHT) and N-acetylcysteine (NAC) modified TNF-alpha production in stimulated and unstimulated alveolar macrophages from lung transplant recipients in vitro.

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          Author and article information

          Journal
          Transplantation
          Transplantation
          Ovid Technologies (Wolters Kluwer Health)
          0041-1337
          0041-1337
          Aug 15 1998
          : 66
          : 3
          Affiliations
          [1 ] Wallenberg Laboratory, Sahlgrenska University Hospital, Göteborg, Sweden. Lillemor.Mattsson@wlab.wall.gu.SE
          Article
          10.1097/00007890-199808150-00014
          9721806
          6b4c67f7-b68a-4463-80aa-29d55ee7475f
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