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      Vascular Risk Factors Linked to Multiple Lacunar Infarcts

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          Background: The pathogenesis of lacunar infarcts is still incompletely established. Data from the literature suggest that vascular risk factors differ among patients with multiple (MLI) and single lacunar infarcts (SLI). We reexamined this hypothesis using stricter inclusion criteria and a less selected study population. Methods: We evaluated 136 patients consecutively admitted for first-ever minor stroke to a general hospital with the characteristics of a community hospital. Vascular risk factors were studied by univariate and multivariate statistical analyses among the following subgroups of patients, classified according to CT findings: (a) with lacunar infarct; (b) with nonlacunar infarct (NLI); (c) with SLI; (d) with MLI; (e) with single, either lacunar or nonlacunar, infarct. Results: No significant difference was observed between patients with lacunar infarcts and patients with NLI. Compared to patients with SLI or NLI, patients with MLI had significantly more often a family history of hypertension, cardiomegaly on the chest radiograph and CT leukoaraiosis as well as a higher systolic and diastolic blood pressure on admission. Logistic regression analysis selected CT leukoaraiosis, Rx cardiomegaly and admission diastolic blood pressure as independent, significant predictors of MLI. Conclusion: In patients with first-ever minor stroke, the risk factor profile differs according to the evidence of SLI or MLI on the CT scan. In terms of risk factors, patients with SLI seem more similar to those with NLI than those with MLI. Based on the predicting effect of variables linked with type and severity of arterial hypertension, the CT appearance of MLI might express a more univocal and specific cerebrovascular pathology (hypertensive arteriolosclerosis).

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          Author and article information

          Cerebrovasc Dis
          Cerebrovascular Diseases
          S. Karger AG
          June 1998
          24 April 1998
          : 8
          : 3
          : 152-157
          a Department of Internal Medicine, 1st Division, and b Department of Internal Medicine, 2nd Division, San Giovanni di Dio Hospital, Florence, and c Department of Neurological and Psychiatric Sciences, University of Florence, Italy
          15841 Cerebrovasc Dis 1998;8:152–157
          © 1998 S. Karger AG, Basel

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          Tables: 5, References: 19, Pages: 6
          Original Paper


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