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      Ion Transport in Tonic and Phasic Vascular Smooth Muscle and Changes during Deoxycorticosterone Hypertension

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          Abstract

          The washout of radioisotopes was studied in aorta, femoral artery and portal mesenteric vein from controls and rats made hypertensive with injection of deoxycorticosterone (DOC) acetate. Experiments were also conducted on tonic (pulmonary artery) and phasic (portal mesenteric vein) smooth muscle from rabbits. The rate constants for the washout of <sup>42</sup>K, <sup>36</sup>Cl and <sup>24</sup>Na from aorta were significantly elevated in the DOC hypertensives. Acute removal of extracellular K slowed the washout of <sup>24</sup>Na by 50%, however, the rate constant for the DOC group remained higher than the controls. Increased turnover of <sup>42</sup>K was also observed in the femoral artery and in a vessel (portal mesenteric vein) not exposed to the effects of high blood pressure in the rat. The rate constants for the washout of <sup>42</sup>K, <sup>36</sup>Cl and <sup>24</sup>Na from phasic smooth muscle in rabbit were greater than the tonic type. Ouabain significantly slowed <sup>24</sup>Na washout, however, the rate constant for the portal mesenteric vein remained higher than the pulmonary artery. DOC hypertension was associated with increased ion transport at several vascular sites. A similar change was observed for the phasic vascular smooth muscle from normal rabbits. A question is raised whether increased spontaneous activity of arteries reported to accompany DOC hypertension is the consequence of a membrane in transition from tonic to phasic behavior.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          978-3-8055-2857-3
          978-3-318-02028-1
          1018-1172
          1423-0135
          1978
          1978
          18 September 2008
          : 15
          : 1-3
          : 83-92
          Affiliations
          Department of Physiology, University of Missouri, Columbia, Mo.
          Article
          158155 Blood Vessels 1978;15:83–92
          10.1159/000158155
          © 1978 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 10
          Categories
          Molecular and Cellular Aspects of Vascular Smooth Muscle in Health and Disease

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