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      Abnormal neural oscillations and synchrony in schizophrenia.

      Nature reviews. Neuroscience

      physiopathology, Schizophrenia, physiology, Neurons, Nerve Net, Humans, psychology, Cortical Synchronization, Biological Clocks, Animals

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          Abstract

          Converging evidence from electrophysiological, physiological and anatomical studies suggests that abnormalities in the synchronized oscillatory activity of neurons may have a central role in the pathophysiology of schizophrenia. Neural oscillations are a fundamental mechanism for the establishment of precise temporal relationships between neuronal responses that are in turn relevant for memory, perception and consciousness. In patients with schizophrenia, the synchronization of beta- and gamma-band activity is abnormal, suggesting a crucial role for dysfunctional oscillations in the generation of the cognitive deficits and other symptoms of the disorder. Dysfunctional oscillations may arise owing to anomalies in the brain's rhythm-generating networks of GABA (gamma-aminobutyric acid) interneurons and in cortico-cortical connections.

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          Journal
          10.1038/nrn2774
          20087360

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