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      Brain injury biomarkers and inflammatory markerslike pronostic factors on mortality in patients with spontaneous intracranial hemorrhage (medical-adults intensive care)

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          Abstract

          Objective To value the usefulness of brain injury biomarkers (BIB) and inflammatory markers (IM) to predict mortality in spontaneous intracranial hemorrhage patients (SIH). Material and Methods BIB (D Dimer (DD), BNP and CRP) were determined at admission, 1, 2, 3 and 7th day; IM at admission and 7th day. Descriptive analysis % and Median (minimal/ maximum). Independent samples T-student to compare means (p < 0.05). A binary logistic multivariate regression analysis was performed (95% CI OR). Results 103 patients with SIH. 66% were men. Age 61.8 (± 12.7). Overall Mortallity 37%. ICU stay 7 days (1-55). Glasgow Coma Scale 12 (3-15). SIH 20.18 cc volume (1-252). The univariate correlation between of BIB and MI with mortality in Table 1. In mutivariate analysis: protective factors were BNP at admission (OR 1.1, 95% CI 1.1-1.2 (p 0.02)), DD at 7th day (OR 1.1, 95% CI 1.1-1.3 (p 0.009)) and Prealbumin at 7th day (OR 0.9, 95% CI 0.8-0.9 (p 0.03)). Table 1 Relationship brain injury biomarkers and inflammatory markers with mortality; Median ± SD. BIB: Brain injury biomarkers; IM: Inflammatory markers; BNP: Brain natriuretic peptide; DD: D Dimer. BIB and IM Dead Alive P BNP (pg/ml) Admission 223,5 ± 318,46 82.41 ± 95,55 0,001 24 h 175,96 ± 202,08 87.84 ± 77,19 0,002 48 h 142.32 ± 156,01 94.12 ± 82,66 0,04 DD (µg/L) 48 h 1915,8 ± 1631,5 883,7 ± 1368,6 0, 001 72 h 2525,27 ± 2142,47 1051.92 ± 1254,15 0,000 7th d 3677.07 ± 2224,72 2150.9 ± 1820,42 0,005 Leukocytosis Admission 12037,5 ± 4806,8 10241,8 ± 3624,2 0,03 Albumin (g/dl) Admission 3,4 ± 0,52 3,7 ± 0,55 0,01 Prealbúmin (mg/dl) Admission 7th d 18,97 ± 6,78 16,74 ± 7,28 22.30 ± 5,36 21,22 ± 8,03 0,008 0,02 Conclusions BNP at admission, 24 h and 48 h and DD as late marker at 48 h, 72 h and 7th day were correlated with mortality in patients with SIH. IM correlated with mortality: leukocytosis, albumin and prealbumin at admission and prealbumin, ferritin and haptoglobin at 7th day. Multivariate analysis found significance for increased risk of death BNP at admission and DD at 7th day; and protective factor was Prealbumin at 7th day.

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          Author and article information

          Conference
          Intensive Care Med Exp
          Intensive Care Med Exp
          Intensive Care Medicine Experimental
          Springer International Publishing (Cham )
          2197-425X
          1 October 2015
          1 October 2015
          December 2015
          : 3
          Issue : Suppl 1 Issue sponsor : The publication charges for this supplement were funded by Intensive Care Medicine Experimental.
          : A852
          Affiliations
          Medical Intensive Care Unit, Hospital Clinic Universitario de Valencia, Valencia, Spain
          Article
          992
          10.1186/2197-425X-3-S1-A852
          4796183
          6b98fd6b-f702-4b19-ad5c-286f0cb0a033
          © Aguillón Prada et al.; 2015

          This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

          ESICM LIVES 2015
          Berlin, Germany
          3-7 October 2015
          History
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          Poster Presentation
          Custom metadata
          © The Author(s) 2015

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