Recent Advances in Enantioselective Desymmetrizations of Prochiral Oxetanes

Abstract

Strain relief of oxetanes offers a plethora of opportunities for the synthesis of chiral alcohols and ethers. In this context, enantioselective desymmetrization has been identified as a powerful tool to construct molecular complexity and this has led to the development of elegant strategies on the basis of transition metal, Lewis acid, and Brønsted acid catalysis. This review highlights recent examples that harness the inherent reactivity of prochiral oxetanes and offers an outlook on the immense possibilities for synthetic application.

Abstract

Prochiral oxetanes are excellent candidates for the synthesis of chiral alcohols and ethers via enantioselective desymmetrization. Recent methods relying on transition metal, Lewis acid, and Brønsted acid catalysis allow access to a remarkably diverse set of compounds, which are highlighted and put into context.