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Angiosarcoma
Author(s):
Robin J Young
,
Nicola J Brown
,
Malcolm W Reed
,
David Hughes
,
Penella J Woll
Publication date
Created:
October 2010
Publication date
(Print):
October 2010
Journal:
The Lancet Oncology
Publisher:
Elsevier BV
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There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Angiosarcomas are rare soft-tissue sarcomas of endothelial cell origin that have a poor prognosis. They can arise anywhere in the body, most commonly presenting as cutaneous disease in elderly white men, involving the head and neck and particularly the scalp. They can be caused by therapeutic radiation or chronic lymphoedema and hence secondary breast angiosarcomas are an important subgroup. Recent work has sought to establish the molecular biology of angiosarcomas and identify specific targets for treatment. Interest is now focused on trials of vascular-targeted drugs, which are showing promise in the control of angiosarcomas. In this review we discuss angiosarcoma and its current management, with a focus on clinical trials investigating the treatment of advanced disease. Copyright © 2010 Elsevier Ltd. All rights reserved.
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Journal
Title:
The Lancet Oncology
Abbreviated Title:
The Lancet Oncology
Publisher:
Elsevier BV
ISSN (Print):
14702045
Publication date Created:
October 2010
Publication date (Print):
October 2010
Volume
: 11
Issue
: 10
Pages
: 983-991
Article
DOI:
10.1016/S1470-2045(10)70023-1
PubMed ID:
20537949
SO-VID:
6ba8e644-5b95-46a5-afd0-550d023d3530
Copyright ©
© 2010
License:
https://www.elsevier.com/tdm/userlicense/1.0/
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