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      Hepcidin: a real-time biomarker of iron need.

      1
      Metallomics : integrated biometal science
      Royal Society of Chemistry (RSC)

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          Abstract

          There are numerous blood-based biomarkers for assessing iron stores, but all come with certain limitations. Hepcidin is a hormone primarily produced in the liver that has been proposed as the 'master regulator' of dietary uptake and iron metabolism, and has enormous potential to provide a 'real time' indicator of body iron levels. In this Minireview, the biochemical function of hepcidin in regulating iron levels will be discussed, with a specific focus on how hepcidin can aid in the assessment of iron stores and clinical diagnosis of iron deficiency, iron deficiency anaemia and other iron-related disorders. The role hepcidin itself plays in diseases of iron metabolism will be examined, and current efforts to translate hepcidin assays into the clinic will be critically appraised. Potential limitations of hepcidin as a marker of iron need will also be addressed, as well as the development of new therapies that directly target the hormone that sits atop the hierarchy of systemic iron metabolism.

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          Author and article information

          Journal
          Metallomics
          Metallomics : integrated biometal science
          Royal Society of Chemistry (RSC)
          1756-591X
          1756-5901
          May 04 2017
          Affiliations
          [1 ] The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, Victoria 3052, Australia. dominic.hare@florey.edu.au.
          Article
          10.1039/c7mt00047b
          28470295
          6bc3d729-7b89-4fa2-97e8-93c6bf27c0f6
          History

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