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      Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy.

      Journal of the National Cancer Institute
      Oxford University Press (OUP)

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          Abstract

          Tumorigenic breast cancer cells that express high levels of CD44 and low or undetectable levels of CD24 (CD44(>)/CD24(>/low)) may be resistant to chemotherapy and therefore responsible for cancer relapse. These tumorigenic cancer cells can be isolated from breast cancer biopsies and propagated as mammospheres in vitro. In this study, we aimed to test directly in human breast cancers the effect of conventional chemotherapy or lapatinib (an epidermal growth factor receptor [EGFR]/HER2 pathway inhibitor) on this tumorigenic CD44(>) and CD24(>/low) cell population.

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          Journal
          18445819
          10.1093/jnci/djn123

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