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      Platelet count and erythrocyte sedimentation rate are good predictors of Kawasaki disease: ROC analysis

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          Abstract

          Background and Aims: Kawasaki disease (KD) is the leading cause of acquired pediatric cardiac disease and requires a timely diagnosis. Available effective therapy is ideally administered within 10 days of illness diagnosis. Recent reports of several laboratory tests in KD have been published. In this study, we aimed to evaluate the sensitivity and specificity of several laboratory tests. Methods: We performed a retrospective study of consecutive patients diagnosed with KD from January to December 2008. We studied the sensitivity and specificity of several different tests [T‐cell subgroups, platelet count, erythrocyte sedimentation rate (ESR), and C‐reactive protein (CRP)] to predict KD using receiveroperator characteristic curve analysis. Results: No significant difference was demonstrated in T‐cell subgroups between patients with KD and referent patients ( P>0.05). However, platelet count, ESR, and CRP were significantly higher in patients with KD than in referent patients ( P<0.05). ESR showed a sensitivity of 93.9% and specificity of 83.3% with a cut‐off of 15 mm/hr (area under the curve [AUC], 89.1%; P=0.03). Platelet count showed a sensitivity of 70.6% and specificity of 75% with a cut‐off of 336.5×10 9/l (AUC, 71.2%; P=0.03). Conclusions: These results indicate that platelet count and ESR are good predictors of KD. J. Clin. Lab. Anal. 24:385–388, 2010. © 2010 Wiley‐Liss, Inc.

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          Author and article information

          Contributors
          songxyxm@hotmail.com
          Journal
          J Clin Lab Anal
          J. Clin. Lab. Anal
          10.1002/(ISSN)1098-2825
          JCLA
          Journal of Clinical Laboratory Analysis
          Wiley Subscription Services, Inc., A Wiley Company (Hoboken )
          0887-8013
          1098-2825
          18 November 2010
          2010
          : 24
          : 6 ( doiID: 10.1002/jcla.v24:6 )
          : 385-388
          Affiliations
          [ 1 ]Clinical Laboratory Department, The First Hospital Affiliated to Xiamen University, Xiamen, China
          Author notes
          [*] [* ]Clinical Laboratory Department, The First Hospital Affiliated to Xiamen University, Xiamen, China
          Article
          PMC6647660 PMC6647660 6647660 JCLA20414
          10.1002/jcla.20414
          6647660
          21089168
          6bd74f70-a4f4-4b1b-9323-d7fb280c0b94
          © 2010 Wiley‐Liss, Inc.
          History
          : 09 August 2009
          : 20 July 2010
          Page count
          Figures: 2, Tables: 4, References: 16, Pages: 4
          Categories
          Original Article
          Original Articles
          Custom metadata
          2.0
          2010
          Converter:WILEY_ML3GV2_TO_NLMPMC version:5.6.2.1 mode:remove_FC converted:10.05.2019

          C‐reactive protein,Kawasaki disease, T‐cell,erythrocyte sedimentation rate,platelet count

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