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      Anti-inflammatory lipid mediators and insights into the resolution of inflammation.

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          Abstract

          The pro-inflammatory signalling pathways and cellular mechanisms that initiate the inflammatory response have become increasingly well characterized. However, little is known about the mediators and mechanisms that switch off inflammation. Recent data indicate that the resolution of inflammation is an active process controlled by endogenous mediators that suppress pro-inflammatory gene expression and cell trafficking, as well as induce inflammatory-cell apoptosis and phagocytosis, which are crucial determinants of successful resolution. This review focuses on this emerging area of inflammation research and describes the mediators and mechanisms that are currently stealing the headlines.

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          Author and article information

          Journal
          Nat Rev Immunol
          Nature reviews. Immunology
          Springer Science and Business Media LLC
          1474-1733
          1474-1733
          Oct 2002
          : 2
          : 10
          Affiliations
          [1 ] Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093-0636, USA. tolawrence@ucsd.edu
          Article
          nri915
          10.1038/nri915
          12360216
          6be3a4e3-1c52-4a99-8152-6541c7d8d281
          History

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