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      Bacillus thuringiensis: A story of a successful bioinsecticide

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      Insect Biochemistry and Molecular Biology
      Elsevier BV

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          Abstract

          Bacillus thuringiensis (Bt) bacteria are insect pathogens that rely on insecticidal pore forming proteins known as Cry and Cyt toxins to kill their insect larval hosts. At least four different non-structurally related families of proteins form the Cry toxin group of toxins. The expression of certain Cry toxins in transgenic crops has contributed to an efficient control of insect pests resulting in a significant reduction in chemical insecticide use. The mode of action of the three domain Cry toxin family involves sequential interaction of these toxins with several insect midgut proteins facilitating the formation of a pre-pore oligomer structure and subsequent membrane insertion that leads to the killing of midgut insect cells by osmotic shock. In this manuscript we review recent progress in understanding the mode of action of this family of proteins in lepidopteran, dipteran and coleopteran insects. Interestingly, similar Cry-binding proteins have been identified in the three insect orders, as cadherin, aminopeptidase-N and alkaline phosphatase suggesting a conserved mode of action. Also, recent data on insect responses to Cry toxin attack is discussed. Finally, we review the different Bt based products, including transgenic crops, that are currently used in agriculture. Copyright © 2011 Elsevier Ltd. All rights reserved.

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          Author and article information

          Journal
          Insect Biochemistry and Molecular Biology
          Insect Biochemistry and Molecular Biology
          Elsevier BV
          09651748
          July 2011
          July 2011
          : 41
          : 7
          : 423-431
          Article
          10.1016/j.ibmb.2011.02.006
          3689885
          21376122
          6c0bee5c-e18d-4860-8654-08206a05f760
          © 2011

          https://www.elsevier.com/tdm/userlicense/1.0/

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