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      Polysaccharide-based antibiofilm surfaces.

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          Abstract

          Surface treatment by natural or modified polysaccharide polymers is a promising means to fight against implant-associated biofilm infections. The present review focuses on polysaccharide-based coatings that have been proposed over the last ten years to impede biofilm formation on material surfaces exposed to bacterial contamination. Anti-adhesive and bactericidal coatings are considered. Besides classical hydrophilic coatings based on hyaluronic acid and heparin, the promising anti-adhesive properties of the algal polysaccharide ulvan are underlined. Surface functionalization by antimicrobial chitosan and derivatives is extensively surveyed, in particular chitosan association with other polysaccharides in layer-by-layer assemblies to form both anti-adhesive and bactericidal coatings.

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          Author and article information

          Journal
          Acta Biomater
          Acta biomaterialia
          Elsevier BV
          1878-7568
          1742-7061
          Jan 2016
          : 30
          Affiliations
          [1 ] CNRS, UMR 6270, PBS Laboratory, Normandie Univ, UR, 76821 Mont-Saint-Aignan cedex, France. Electronic address: guy-alain.junter@univ-rouen.fr.
          [2 ] CNRS, UMR 6270, PBS Laboratory, Normandie Univ, UR, 76821 Mont-Saint-Aignan cedex, France.
          Article
          S1742-7061(15)30187-2
          10.1016/j.actbio.2015.11.010
          26555378
          6c12a2e8-ec9d-4d6c-a96c-eadd199b4376

          Surface functionalization,Chitosan,Biomaterial,Bacterial adhesion,Bactericidal coating

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