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Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe.
Michel Warny
1 ,
Jacques Pepin ,
Aiqi Fang ,
George Killgore ,
Angela Thompson ,
Jon Brazier ,
Eric Frost ,
L Clifford McDonald
September 27 2005
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Abstract
Toxins A and B are the primary virulence factors of Clostridium difficile. Since 2002, an epidemic of C difficile-associated disease with increased morbidity and mortality has been present in Quebec province, Canada. We characterised the dominant strain of this epidemic to determine whether it produces higher amounts of toxins A and B than those produced by non-epidemic strains.