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      Association of serum levels of AngII, KLK1, and ACE/KLK1 polymorphisms with acute myocardial infarction induced by coronary artery stenosis

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          Abstract

          Introduction:

          The study aims to confirm the association of acute myocardial infarction (AMI) with serum angiotensin II (AngII), kallikrein1 (KLK1), and ACE/KLK1 polymorphisms.

          Materials and methods:

          Serum AngII/KLK1 levels and ACE and KLK1 genotypes were determined in 208 patients with AMI and 216 normal controls. Binary logistic regression was used for data analysis.

          Results:

          The differences in serum AngII levels were statistically significant between the groups. After adjusting for potential confounding factors, high serum levels of AngII and KLK1 significantly increased the risk of AMI. The individuals with ACE DD and KLK1 GG genotypes significantly increased the risk of AMI compared with those harboring the ACE II and KLK1 AA genotypes (OR = 8.77, 95% CI = 1.74–44.16).

          Conclusions:

          (1) Increasing the serum levels of AngII increased the risk of AMI. (2) The risk of AMI increased significantly when the serum levels of AngII and KLK1 simultaneously increased. (3) Individuals with the combined genotypes of ACE DD and KLK1 GG showed significantly increased risk of AMI compared with those with the combined genotypes of ACE II and KLK1 AA.

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          Most cited references 38

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          Inflammation, immunity, and hypertension.

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            Hints of hidden heritability in GWAS.

             Greg Gibson (2010)
            Although susceptibility loci identified through genome-wide association studies (GWAS) typically explain only a small proportion of the heritability, a classical quantitative genetic analysis now argues that considering together all common SNPs can explain a large proportion of the heritability of these complex traits. A related study provides recommendations for the sample sizes needed in future GWAS to identify additional susceptibility loci.
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              Bioregulation of kinins: kallikreins, kininogens, and kininases.

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                Author and article information

                Journal
                J Renin Angiotensin Aldosterone Syst
                J Renin Angiotensin Aldosterone Syst
                JRA
                spjra
                Journal of the Renin-Angiotensin-Aldosterone System: JRAAS
                SAGE Publications (Sage UK: London, England )
                1470-3203
                1752-8976
                01 June 2016
                Apr-Jun 2016
                : 17
                : 2
                Affiliations
                [1 ]The Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, China
                [2 ]Department of cardiology, Qilu Hospital, Shandong University, China
                [3 ]Department of obstetrics and gynecology, Qilu Hospital, Shandong University, China
                [4 ]Department of emergency, Qilu Hospital, Shandong University, China
                Author notes
                Da-qing Li, The Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Department of cardiology, Qilu Hospital, Shandong University, 107# Wenhuaxi Road, Jinan, 250012, China. Email: qingdali611@ 123456163.com
                Article
                10.1177_1470320316655037
                10.1177/1470320316655037
                5843928
                27329205
                © The Author(s) 2016

                This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License ( http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page ( https://us.sagepub.com/en-us/nam/open-access-at-sage).

                Categories
                Original Article
                Custom metadata
                April-June 2016

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