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      Epiretinal Membrane of Proliferative Diabetic Retinopathy: An Immunohistochemical Study

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          Abstract

          Nineteen cases of epiretinal membrane (ERM) in proliferative diabetic retinopathy were studied using immunohistochemical methods. Antibodies against type I-IV collagen, fibronectin (FN), glial fibrillary acidic protein (GFAP), vimentin and the monoclonal antibody (MAB) against human Müller cells were used to examine the membranes. Type II collagen was found on one side of the ERMs in 95% of the cases. The other types of collagen, FN and vimentin were also identified in most cases. Müller cells (GFAP- and MAB-positive) were found in 2/19 cases (11 %), and astrocytes (GFAP-positive but MAB-negative) were found in 10/19 cases (53%). These results suggest that type II collagen (vitreal collagen) may act as a scaffolding in the formation of ERMs and that glial elements of the ERMs consist mainly of astrocytes.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1993
          1993
          11 December 2009
          : 25
          : 5
          : 289-294
          Affiliations
          aDepartment of Ophthalmology, Kyoto University, Faculty of Medicine, Kyoto; bDepartment of Ophthalmology, Aichi Medical University, Aichi; cDepartment of Tissue Physiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
          Article
          267327 Ophthalmic Res 1993;25:289–294
          10.1159/000267327
          8259261
          © 1993 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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