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      • Record: found
      • Abstract: found
      • Article: found

      Epiretinal Membrane of Proliferative Diabetic Retinopathy: An Immunohistochemical Study

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          Abstract

          Nineteen cases of epiretinal membrane (ERM) in proliferative diabetic retinopathy were studied using immunohistochemical methods. Antibodies against type I-IV collagen, fibronectin (FN), glial fibrillary acidic protein (GFAP), vimentin and the monoclonal antibody (MAB) against human Müller cells were used to examine the membranes. Type II collagen was found on one side of the ERMs in 95% of the cases. The other types of collagen, FN and vimentin were also identified in most cases. Müller cells (GFAP- and MAB-positive) were found in 2/19 cases (11 %), and astrocytes (GFAP-positive but MAB-negative) were found in 10/19 cases (53%). These results suggest that type II collagen (vitreal collagen) may act as a scaffolding in the formation of ERMs and that glial elements of the ERMs consist mainly of astrocytes.

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          Author and article information

          Journal
          Journal ID (publisher-id): ORE
          Journal ID (nlm-ta): Ophthalmic Res
          Journal ID (doi): 10.1159/issn.0030-3747
          Title: Ophthalmic Research
          Publisher: S. Karger AG
          ISSN (Print): 0030-3747
          ISSN (Electronic): 1423-0259
          Publication date Subscription-year: 1993
          Publication date (Print): 1993
          Publication date (Electronic): 11 December 2009
          Volume: 25
          Issue: 5
          Pages: 289-294
          Affiliations
          aDepartment of Ophthalmology, Kyoto University, Faculty of Medicine, Kyoto; bDepartment of Ophthalmology, Aichi Medical University, Aichi; cDepartment of Tissue Physiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
          Article
          Publisher ID: 267327 Other ID: Ophthalmic Res 1993;25:289–294
          DOI: 10.1159/000267327
          PubMed ID: 8259261
          SO-VID: 6c3745cd-849d-439a-a99f-9f485462ccb0
          Copyright © © 1993 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 15 September 1993
          Date accepted : 23 February 1993
          Page count
          Pages: 6
          Categories
          Subject: Original Paper

          ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
          Keywords: Fibronectin,Monoclonal antibody to human Müller cell,Collagen,Glial fibrillary acidic protein,Proliferative diabetic retinopathy,Epiretinal membrane
          Data availability:
          ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
          Keywords: Fibronectin, Monoclonal antibody to human Müller cell, Collagen, Glial fibrillary acidic protein, Proliferative diabetic retinopathy, Epiretinal membrane

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