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      PCSK9: a convertase that coordinates LDL catabolism.

      Journal of Lipid Research

      pharmacology, Animals, Apoptosis, Biological Transport, Cholesterol, LDL, metabolism, Humans, Protein Binding, Serine Endopeptidases, chemistry, genetics, Serine Proteinase Inhibitors

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          Abstract

          The identification and characterization of proprotein convertase subtilisin-like/kexin type 9 (PCSK9) have provided new insights into LDL metabolism and the causal role of LDL in coronary heart disease (CHD). PCSK9 is a secreted protease that mediates degradation of the LDL receptor by interacting with the extracellular domain and targeting the receptor for degradation. Individuals with loss-of-function mutations in PCSK9 have reduced plasma levels of LDL cholesterol and are protected from CHD; these observations have validated PCSK9 as a therapeutic target and suggested new approaches for the treatment and prevention of CHD.

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          Author and article information

          Journal
          19020338
          2674748
          10.1194/jlr.R800091-JLR200

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