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      Hepatoprotective and nephroprotective effects of sardinelle (Sardinella aurita) protein hydrolysate against ethanol-induced oxidative stress in rats.

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          Abstract

          Ethanol consumption-induced oxidative stress that is a major etiological factor has been proven to play important roles in organs' injury. In the present study, we investigated the protective effect of fish protein hydrolysate prepared from the heads and viscera of sardinelle (Sardinella aurita) (SPH) against the toxicity of ethanol on the liver and kidney of adult male rats. Animals were divided into four groups of six animals each: group C served as control, group Eth received 30 % ethanol solution at the dose of 3 g/kg body weight, group SPH received only 7.27 mg of SPH/kg body weight, and group Eth-SPH received ethanol and SPH simultaneously at the doses of 30 % and 7.27 mg/kg body weight, respectively. All groups were treated by gavage way for 15 days. Ethanol treatment decreased the defense enzymatic system including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), which increased after the co-administration of SPH. Malondialdehyde (MDA) and toxicity biomarker levels such as aspartate transaminase (AST) and alanine transaminase (ALT) and alcaline phosphatase (ALP) and gamma-glutamyl transaminase (GGT) activities were enhanced after chronic ethanol treatment and reduced by co-treatment with SPH. The histological examination of the liver and kidney confirmed biochemical changes in ethanol-treated rats and demonstrated the protective role of SPH.

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          Author and article information

          Journal
          Environ Sci Pollut Res Int
          Environmental science and pollution research international
          Springer Science and Business Media LLC
          1614-7499
          0944-1344
          Jan 2017
          : 24
          : 2
          Affiliations
          [1 ] Unité Toxicologie et Microbiologie Environnemental et Santé, Faculté des Sciences de Sfax, BP 1171, 3000, Sfax, Tunisia. zeineb.kamoun@gmail.com.
          [2 ] Departement des Sciences de la vie, Université de Sfax-Faculté des Sciences de Sfax, BP 1171, 3000, Sfax, Tunisia. zeineb.kamoun@gmail.com.
          [3 ] Laboratoire de Génie Enzymatique et de Microbiologie, Ecole Nationale d'Ingénieurs de Sfax, 3038, Sfax, Tunisia.
          [4 ] Unité Enzymes et Bioconversion, Ecole nationale d'Ingénieurs, BP 1171, 3038, Sfax, Tunisia.
          [5 ] Laboratoire de Biochimie, CHU Hédi Chaker, 3029, Sfax, Tunisia.
          [6 ] Laboratoire d'Anatomie et de Cytologie Pathologique, CHU Habib Bourguiba, 3023, Sfax, Tunisia.
          [7 ] Laboratoire Biotechnologie des Plantes Appliquée à l'Amélioration des Cultures, Faculté des Sciences de Sfax, BP 1171, 3000, Sfax, Tunisia.
          [8 ] Unité Toxicologie et Microbiologie Environnemental et Santé, Faculté des Sciences de Sfax, BP 1171, 3000, Sfax, Tunisia.
          Article
          10.1007/s11356-016-7424-4
          10.1007/s11356-016-7424-4
          27783246

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