15
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Immunophenotypic characterization of acute leukemia at a public oncology reference center in Maranhão, northeastern Brazil Translated title: Caracterização imunofenotípica das leucemias agudas em um centro oncológico de referência público no Maranhão, Nordeste do Brasil

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          CONTEXT AND OBJECTIVES: The incidence of acute leukemia (AL) subtypes varies according to geographical distribution. The aim here was to determine the incidence of morphological and immunophenotypic AL subtypes in the state of Maranhão, Brazil, and to correlate the expression of aberrant phenotypes in children with acute lymphoblastic leukemia (ALL) with prognostic factors. DESIGN AND SETTING: Single prospective cohort study at a public oncology reference center in Maranhão. METHODS: Seventy AL cases were diagnosed between September 2008 and January 2010. For the diagnosis, complete blood cell counts, myelograms (at diagnosis and at the end of the induction phase), cytochemical analysis and immunophenotyping were performed. RESULTS: Among adult patients (n = 22), the incidence of AL types was: ALL (22.7%) and acute myeloid leukemia (AML) (77.3%). The subtype AML M0 occurred most frequently (29.4%). In children (n = 48), the types were: AML (18.7%), most frequently subtype AML M4 (33.4%); biphenotypic acute leukemia (BAL) (4.2%); and ALL (77.1%), including the subtypes B-ALL (72.9%) and T-ALL (27.1%). Among the children with ALL, there were no statistically significant differences between patients with and without aberrant phenotypes, in relation to hematological parameters and treatment response. CONCLUSION: This work demonstrates that the frequencies of AML M0 cases among adults and T-ALL cases among children in Maranhão were high. This suggests that there may be differences in AML subtype incidence, as seen with ALL subtypes, in different regions of Brazil. No association was found between the expression of aberrant phenotypes and prognostic factors, in children with ALL.

          Translated abstract

          CONTEXTO E OBJETIVOS: A incidência dos subtipos de leucemias agudas (LA) tem mostrado variações em relação à distribuição geográfica. Objetivou-se determinar a incidência dos subtipos morfológicos e imunofenotípicos de LA no estado do Maranhão, Brasil, e relacionar a expressão de fenótipos aberrantes em crianças com leucemia linfoblástica aguda (LLA) com fatores prognósticos. TIPO DE ESTUDO E LOCAL: Estudo de coorte único prospectivo em um centro oncológico de referência público no Maranhão. MÉTODOS: Diagnosticaram-se 70 casos de LA no período de setembro de 2008 a janeiro de 2010. No diagnóstico, realizaram-se hemogramas, mielogramas (no diagnóstico e ao final da fase de indução), citoquímica e imunofenotipagem. RESULTADOS: Nos pacientes adultos (n = 22), as incidências dos tipos de LA foram: LLA (22,7%) e leucemia mieloide aguda (LMA) (77,3%), sendo o subtipo LMA M0 mais frequente (29,4%). Em crianças (n = 48): LMA (18,7%), subtipo LMA M4 mais frequente (33,4%), leucemia bifenotípica aguda (BAL) (4,2%) e LLA (77,1%), sendo os subtipos LLA-B (72,9%) e LLA-T (27,1%). Na LLA, em crianças, não se encontrou diferença estatisticamente significante entre pacientes com e sem fenótipos aberrantes, em relação aos parâmetros hematológicos e resposta ao tratamento. CONCLUSÃO: Esta pesquisa demonstra elevada frequência de casos de LMA M0 em adultos, bem como das LLA-T em crianças no Maranhão, sugerindo que podem haver diferenças na incidência dos subtipos das LMA, assim como dos subtipos de LLA, em diferentes regiões do Brasil. Não foi encontrada associação entre a expres de fenótipos aberrantes e fatores prognósticos em crianças com LLA.

          Related collections

          Most cited references 83

          • Record: found
          • Abstract: found
          • Article: not found

          Acute myeloid leukaemia.

          Acute myeloid leukaemia (AML) is a heterogeneous clonal disorder of haemopoietic progenitor cells and the most common malignant myeloid disorder in adults. The median age at presentation for patients with AML is 70 years. In the past few years, research in molecular biology has been instrumental in deciphering the pathogenesis of the disease. Genetic defects are thought to be the most important factors in determining the response to chemotherapy and outcome. Whereas significant progress has been made in the treatment of younger adults, the prospects for elderly patients have remained dismal, with median survival times of only a few months. This difference is related to comorbidities associated with ageing and to disease biology. Current efforts in clinical research focus on the assessment of targeted therapies. Such new approaches will probably lead to an increase in the cure rate.
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Acute lymphoblastic leukemia.

              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Proposals for the Classification of the Acute Leukaemias French-American-British (FAB) Co-operative Group

                Bookmark

                Author and article information

                Journal
                spmj
                Sao Paulo Medical Journal
                Sao Paulo Med. J.
                Associação Paulista de Medicina - APM (São Paulo, SP, Brazil )
                1516-3180
                1806-9460
                December 2011
                : 129
                : 6
                : 392-401
                Affiliations
                São Luís Maranhão orgnameUniversidade Federal do Maranhão orgdiv1Department of Pharmacy Brazil
                orgnameUniversidade Federal do Maranhão orgdiv1Masters' degree program on Mother and Child Health
                São Luís Maranhão orgnameUniversidade Federal do Maranhão orgdiv1Department of Public Health Brazil
                São Luís Maranhão orgnameUFMA orgdiv1University Hospital orgdiv2Clinical Research Center Brazil
                São Luís Maranhão orgnameInstituto Maranhense de Oncologia Aldenora Bello Brazil
                Article
                S1516-31802011000600005 S1516-3180(11)12900605
                10.1590/S1516-31802011000600005

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 45, Pages: 10
                Product
                Product Information: website
                Categories
                Original Article

                Comments

                Comment on this article