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      Use of Argatroban for anticoagulation during cardiopulmonary bypass in a patient with heparin allergy.

      European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery

      Anticoagulants, adverse effects, therapeutic use, Cardiopulmonary Bypass, methods, Drug Hypersensitivity, etiology, Heart Valve Prosthesis Implantation, Heparin, Treatment Outcome, contraindications, Humans, Intraoperative Care, Male, Mitral Valve Insufficiency, surgery, Pipecolic Acids, Aged

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          Abstract

          The use of Argatroban for treatment of heparin-induced thrombocytopenia (HIT) and for percutaneous coronary intervention in patients with HIT is well described and FDA approved. The use of Argatroban for cardiopulmonary bypass remains off label and the subject of a few case reports. We report the case of a patient with a heparin allergy requiring cardiopulmonary bypass (CPB) for mitral valve replacement. Argatroban was successfully used as anticoagulation for CPB.

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          18760617
          10.1016/j.ejcts.2008.07.035

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