Serum Lipemia: An Overlooked Cause of Tissue Hypoxia

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Abstract

This article discusses an overlooked subject, namely that serum lipemia affects the transfer of oxygen from the blood to the tissues. It discusses several mechanisms whereby lipemia limits oxygen diffusion. Observations of improved tissue oxygenation in atherosclerotic patients coincident with the clearing of lipemia by heparin are described. Conversely, the adverse effects of increased lipemia after fat meals upon tissue oxygen are noted. The contribution of hypoxia of the arterial wall to atherogenesis is outlined, and its adverse effects in the ischemic heart are listed.

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Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1983

Publication date (Print): 1983

Publication date (Electronic): 07 November 2008

Volume: 70

Issue: 5

Pages: 273-279

Affiliations

Cedars-Sinai Medical Center, Los Angeles, Calif., USA

Article

Publisher ID: 173604 Other ID: Cardiology 1983;70:273–279

DOI: 10.1159/000173604

PubMed ID: 6365311

SO-VID: 6c75cc08-fe0a-43cb-b558-89eee983c64d

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 29 May 1983

Date accepted : 27 July 1983

Page count

Pages: 7

Serum Lipemia: An Overlooked Cause of Tissue Hypoxia

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Karger: Cardiovascular System

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