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      Antibiotic resistance and its cost: is it possible to reverse resistance?

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      Nature Reviews Microbiology
      Springer Science and Business Media LLC

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          Abstract

          Most antibiotic resistance mechanisms are associated with a fitness cost that is typically observed as a reduced bacterial growth rate. The magnitude of this cost is the main biological parameter that influences the rate of development of resistance, the stability of the resistance and the rate at which the resistance might decrease if antibiotic use were reduced. These findings suggest that the fitness costs of resistance will allow susceptible bacteria to outcompete resistant bacteria if the selective pressure from antibiotics is reduced. Unfortunately, the available data suggest that the rate of reversibility will be slow at the community level. Here, we review the factors that influence the fitness costs of antibiotic resistance, the ways by which bacteria can reduce these costs and the possibility of exploiting them.

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          Author and article information

          Journal
          Nature Reviews Microbiology
          Nat Rev Microbiol
          Springer Science and Business Media LLC
          1740-1526
          1740-1534
          April 2010
          March 8 2010
          April 2010
          : 8
          : 4
          : 260-271
          Article
          10.1038/nrmicro2319
          20208551
          6c7ea164-b2eb-4733-b012-9a35640f84f5
          © 2010

          http://www.springer.com/tdm

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