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      Whitepaper: Defining and investigating cognitive reserve, brain reserve, and brain maintenance

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      Alzheimer's & Dementia
      Elsevier BV

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          Abstract

          Several concepts, which in the aggregate get might be used to account for "resilience" against age- and disease-related changes, have been the subject of much research. These include brain reserve, cognitive reserve, and brain maintenance. However, different investigators have use these terms in different ways, and there has never been an attempt to arrive at consensus on the definition of these concepts. Furthermore, there has been confusion regarding the measurement of these constructs and the appropriate ways to apply them to research. Therefore the reserve, resilience, and protective factors professional interest area, established under the auspices of the Alzheimer's Association, established a whitepaper workgroup to develop consensus definitions for cognitive reserve, brain reserve, and brain maintenance. The workgroup also evaluated measures that have been used to implement these concepts in research settings and developed guidelines for research that explores or utilizes these concepts. The workgroup hopes that this whitepaper will form a reference point for researchers in this area and facilitate research by supplying a common language.

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          Author and article information

          Journal
          Alzheimer's & Dementia
          Alzheimer's & Dementia
          Elsevier BV
          15525260
          September 2018
          September 2018
          Article
          10.1016/j.jalz.2018.07.219
          6417987
          30222945
          6c9155bd-6c34-4bc6-a055-8b974e5710d8
          © 2018

          https://www.elsevier.com/tdm/userlicense/1.0/

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