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Cerebrospinal Fluid Neuropeptide Y-like Immunoreactivity Correlates with Impulsive Aggression in Human Subjects
Author(s):
Emil F. Coccaro
,
Royce Lee
,
Tianmin Liu
,
Aleksander A. Mathé
Publication date
Created:
December 2012
Publication date
(Print):
December 2012
Journal:
Biological Psychiatry
Publisher:
Elsevier BV
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Abstract
Neurochemical studies have pointed to a modulatory role in human aggression for a number of central neurotransmitters; some (e.g., serotonin) appear to play an inhibitory role, while others (e.g., vasopressin) appear to play a facilitator role in the modulation of aggression. While recent animal studies of neuropeptide Y (NPY) have suggested a facilitator role for central NPY in the modulation of aggression, no human studies of central NPY have yet been reported regarding aggression. Basal lumbar cerebrospinal fluid (CSF) was obtained from 60 physically healthy subjects with personality disorder (PD) (n=40) and from healthy volunteers (n=20). These samples were then assessed for CSF NPY-like immunoreactivity (NPY-LI) and other neurotransmitter-related species in CSF and correlated with measures of aggression and impulsivity. Cerebrospinal fluid NPY-LI was higher in PD subjects compared with healthy volunteers and in subjects with intermittent explosive disorder compared with those without intermittent explosive disorder. In PD subjects, CSF NPY-LI was directly correlated with composite measures of aggression and impulsivity and a composite measure of impulsive aggression. Group differences in CSF NPY-LI concentration were accounted for by measures of impulsive aggression. These data suggest a direct relationship between CSF NPY-immunoreactivity concentration and measures of impulsive aggression in human subjects. This adds to the complex picture of the central neuromodulatory role of impulsive aggression in human subjects. Copyright © 2012 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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Author and article information
Journal
Title:
Biological Psychiatry
Abbreviated Title:
Biological Psychiatry
Publisher:
Elsevier BV
ISSN (Print):
00063223
Publication date Created:
December 2012
Publication date (Print):
December 2012
Volume
: 72
Issue
: 12
Pages
: 997-1003
Article
DOI:
10.1016/j.biopsych.2012.07.029
PubMed ID:
22985695
SO-VID:
6ca17430-87c1-4135-98d5-cab1662f275e
Copyright ©
© 2012
License:
https://www.elsevier.com/tdm/userlicense/1.0/
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