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      PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells

      , , , ,
      Molecular Cell
      Elsevier BV

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          Abstract

          Through global profiling of genes that were expressed soon after p53 expression, we identified a novel gene termed PUMA (p53 upregulated modulator of apoptosis). The protein encoded by PUMA was found to be exclusively mitochondrial and to bind to Bcl-2 and Bcl-X(L) through a BH3 domain. Exogenous expression of PUMA resulted in an extremely rapid and profound apoptosis that occurred much earlier than that resulting from exogenous expression of p53. Based on its unique expression patterns, p53 dependence, and biochemical properties, PUMA may be a direct mediator of p53-associated apoptosis.

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          Author and article information

          Journal
          Molecular Cell
          Molecular Cell
          Elsevier BV
          10972765
          March 2001
          March 2001
          : 7
          : 3
          : 673-682
          Article
          10.1016/S1097-2765(01)00213-1
          11463391
          6ca34732-9b00-4daa-8020-358ce3ca7065
          © 2001

          https://www.elsevier.com/tdm/userlicense/1.0/

          https://www.elsevier.com/open-access/userlicense/1.0/

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