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      A default mode of brain function: a brief history of an evolving idea.

      1 ,
      NeuroImage
      Elsevier BV

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          Abstract

          The concept of a default mode of brain function arose out of a focused need to explain the appearance of activity decreases in functional neuroimaging data when the control state was passive visual fixation or eyes closed resting. The problem was particularly compelling because these activity decreases were remarkably consistent across a wide variety of task conditions. Using PET, we determined that these activity decreases did not arise from activations in the resting state. Hence, their presence implied the existence of a default mode. While the unique constellation of brain areas provoking this analysis has come to be known as the default system, all areas of the brain have a high level of organized default functional activity. Most critically, this work has called attention to the importance of intrinsic functional activity in assessing brain behavior relationships.

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          Author and article information

          Journal
          Neuroimage
          NeuroImage
          Elsevier BV
          1053-8119
          1053-8119
          Oct 01 2007
          : 37
          : 4
          Affiliations
          [1 ] Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA. marc@npg.wustl.edu
          Article
          S1053-8119(07)00130-9
          10.1016/j.neuroimage.2007.02.041
          17719799
          6ca98601-3f00-4e24-8f64-ebdd34f5e217
          History

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