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      Mercury Exposure Associated with Use of Skin Lightening Products in Jamaica

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          Abstract

          Background.

          Skin bleaching is a major health concern among Jamaicans. A common ingredient in skin lightening products is mercury. Mercury is a toxic substance that can cause damage to the gastrointestinal tract, nervous system and kidneys.

          Objective.

          The objectives of this study were to use different analytical techniques to measure mercury concentrations in popular skin lightening products used in Jamaica and to assess individual levels of mercury exposure based on product usage.

          Methods.

          Sixty skin lightening products were purchased from different vendors across various locations in Jamaica. Each product was initially screened for mercury using a portable handheld energy dispersive X-ray fluorescence (XRF) analyzer. In addition, 25 out of 60 products were further measured using cold vapor atomic absorption spectroscopy (CVAAS). Questionnaires were distributed to users of skin lightening products to determine their usage patterns.

          Results.

          Six products had mercury concentrations above the United States Food and Drug Administration (FDA) allowable limit of 1 ppm, of which three products contained alarmingly high concentrations (i.e. > 400 ppm). The majority of products (57 out of 60) had mercury concentrations below 10 ppm. The mercury concentrations in skin lightening products ranged from 0.05 ppm to 17,547 ppm. In our sample, 51% of women and 49% of men used skin products more than once per day.

          Conclusions.

          On average, creams contained more mercury than lotions and soaps. Individuals who use skin lightening products in Jamaica may be at risk for high mercury exposure, as some popular products were found to have mercury concentrations above the allowable limit.

          Competing Interests.

          The authors declare no competing financial interests.

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          Most cited references18

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          Human Exposure and Health Effects of Inorganic and Elemental Mercury

          Mercury is a toxic and non-essential metal in the human body. Mercury is ubiquitously distributed in the environment, present in natural products, and exists extensively in items encountered in daily life. There are three forms of mercury, i.e., elemental (or metallic) mercury, inorganic mercury compounds, and organic mercury compounds. This review examines the toxicity of elemental mercury and inorganic mercury compounds. Inorganic mercury compounds are water soluble with a bioavailability of 7% to 15% after ingestion; they are also irritants and cause gastrointestinal symptoms. Upon entering the body, inorganic mercury compounds are accumulated mainly in the kidneys and produce kidney damage. In contrast, human exposure to elemental mercury is mainly by inhalation, followed by rapid absorption and distribution in all major organs. Elemental mercury from ingestion is poorly absorbed with a bioavailability of less than 0.01%. The primary target organs of elemental mercury are the brain and kidney. Elemental mercury is lipid soluble and can cross the blood-brain barrier, while inorganic mercury compounds are not lipid soluble, rendering them unable to cross the blood-brain barrier. Elemental mercury may also enter the brain from the nasal cavity through the olfactory pathway. The blood mercury is a useful biomarker after short-term and high-level exposure, whereas the urine mercury is the ideal biomarker for long-term exposure to both elemental and inorganic mercury, and also as a good indicator of body burden. This review discusses the common sources of mercury exposure, skin lightening products containing mercury and mercury release from dental amalgam filling, two issues that happen in daily life, bear significant public health importance, and yet undergo extensive debate on their safety.
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            A Comprehensive Examination of Topographic Thickness of Skin in the Human Face

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              Inorganic mercury and methylmercury in placentas of Swedish women.

              We determined levels of inorganic mercury (I-Hg) and methylmercury in placentas from 119 Swedish women, not selected with respect to high exposure of mercury. Our objective was to relate placental Hg species with maternal and fetal blood concentrations and to evaluate possible associations with selenium. We performed the analyses using automated alkaline solubilization/reduction and cold-vapor atomic fluorescence spectrophotometry. I-Hg levels in placenta increased with an increasing number of maternal dental amalgam fillings (p < 0.001). Despite placental accumulation (median, 1.3 microg/kg; range, 0.18-6.7 microg/kg wet weight), a substantial fraction of maternal blood I-Hg, probably as Hg(0), reached the fetus. Although MeHg transferred easily to the fetus, it also accumulated in the placenta. On average, 60% of placental Hg was in the form of MeHg. The median concentration was 1.8 microg/kg (range, 0-6.2 microg/kg wet weight), more than twice the maternal blood concentration. We found significant associations between MeHg and selenium in both maternal and umbilical cord blood but not in the placenta. The associations were particularly obvious in freshwater fish consumers, probably reflecting that fish is a source of both MeHg and selenium. We found no correlations between I-Hg and selenium. This study increases the understanding of Hg, in its different forms, in human placenta and how they are related to maternal and fetal exposure.
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                Author and article information

                Journal
                J Health Pollut
                hapn
                J Health Pollut
                Journal of Health & Pollution
                Black Smith Institute
                2156-9614
                June 2020
                4 May 2020
                : 10
                : 26
                : 200601
                Affiliations
                [1 ] Department of Physics, Radioecological Lab, The University of the West Indies, Mona Jamaica
                [2 ] Analytical Services Department, Mines and Geology Division, Hope Gardens, Kingston, Jamaica
                [3 ] Pan American Health Organization, Washington DC, USA
                Author notes
                Corresponding author: Phylicia Ricketts, Tel. 876 9272480, phylicia.ricketts02@ 123456uwimona.edu.jm
                Author information
                http://orcid.org/0000-0002-3009-0065
                Article
                i2156-9614-10-26-200601
                10.5696/2156-9614-10.26.200601
                7269324
                6cbd0be0-65bd-4fd5-825d-a3710a08d57a
                © Pure Earth 2020

                This is an Open Access article distributed in accordance with Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0/).

                History
                : 3 September 2019
                : 16 December 2019
                Page count
                Pages: 10
                Categories
                Research

                mercury,skin lightening products,exposure assessment,x-ray fluorescence analyzer,jamaica

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