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      Enfermedad de la válvula aórtica calcificada. Su asociación con la arteriosclerosis

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      Medicina Clínica

      Elsevier BV

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          Abstract

          Calcified aortic valve disease (CAVD) is a prevalent condition, affecting 25% of people older than 65 years. CAVD and atherosclerosis share common risk factors and pathogenic mechanisms. Nevertheless, they present different pathologic lesions. The main factors involved in the pathogenesis of CAVD are genetic predisposition, the process of valvular calcification, deposition of lipoproteins, and chronic inflammation. Studies have suggested a potential benefit from early treatment with angiotensin converting enzyme inhibitors or angiotensin-II receptor blockers, and particularly with statins. Observational studies on risk factors for the CAVD, and randomized clinical trials on primary and secondary prevention in subjects with high risk for the disease, would be necessary to improve the clinical management of CAVD.

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          Author and article information

          Journal
          Medicina Clínica
          Medicina Clínica
          Elsevier BV
          00257753
          May 2011
          May 2011
          : 136
          : 13
          : 588-593
          Article
          10.1016/j.medcli.2010.02.019
          20417530
          © 2011

          https://www.elsevier.com/tdm/userlicense/1.0/

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