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      Collective Epithelial Migration and Cell Rearrangements Drive Mammary Branching Morphogenesis

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      Developmental Cell

      Elsevier BV

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          Abstract

          Epithelial organs are built through the movement of groups of interconnected cells. We observed cells in elongating mammary ducts reorganize into a multilayered epithelium, migrate collectively, and rearrange dynamically, all without forming leading cellular extensions. Duct initiation required proliferation, Rac, and myosin light-chain kinase, whereas repolarization to a bilayer depended on Rho kinase. We observed that branching morphogenesis results from the active motility of both luminal and myoepithelial cells. Luminal epithelial cells advanced collectively, whereas myoepithelial cells appeared to restrain elongating ducts. Significantly, we observed that normal epithelium and neoplastic hyperplasias are organized similarly, suggesting common mechanisms of epithelial growth.

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          Author and article information

          Journal
          Developmental Cell
          Developmental Cell
          Elsevier BV
          15345807
          April 2008
          April 2008
          : 14
          : 4
          : 570-581
          Article
          10.1016/j.devcel.2008.03.003
          2773823
          18410732
          © 2008

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