For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
14
views
14
references
 Top references
cited by
5
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      189
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: not found

      Highly Pathogenic Avian Influenza Clade 2.3.4.4 Subtype H5N6 Viruses Isolated from Wild Whooper Swans, Mongolia, 2020

      brief-report

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          We identified clade 2.3.4.4 highly pathogenic avian influenza A(H5N6) viruses from whooper swans ( Cygnus cygnus) found dead in Mongolia. The identification of these infections in wild birds in this area is of concern because of the potential for virus dissemination during fall migration.

          Related collections

          Most cited references14

          • Record: found
          • Abstract: found
          • Article: not found

          Role for migratory wild birds in the global spread of avian influenza H5N8.

          (2016)
          Avian influenza viruses affect both poultry production and public health. A subtype H5N8 (clade 2.3.4.4) virus, following an outbreak in poultry in South Korea in January 2014, rapidly spread worldwide in 2014-2015. Our analysis of H5N8 viral sequences, epidemiological investigations, waterfowl migration, and poultry trade showed that long-distance migratory birds can play a major role in the global spread of avian influenza viruses. Further, we found that the hemagglutinin of clade 2.3.4.4 virus was remarkably promiscuous, creating reassortants with multiple neuraminidase subtypes. Improving our understanding of the circumpolar circulation of avian influenza viruses in migratory waterfowl will help to provide early warning of threats from avian influenza to poultry, and potentially human, health.
          Article 0 comments Cited 186 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western China.

            Zejun Li, Y. Henry Sun, Q Qi … (2006)
            H5N1 influenza A viruses are widely distributed among poultry in Asia, but until recently, only a limited number of wild birds were affected. During late April through June 2005, an outbreak of H5N1 virus infection occurred among wild birds at Qinghai Lake in China. Here, we describe the features of this outbreak. First identified in bar-headed geese, the disease soon spread to other avian species populating the lake. Sequence analysis of 15 viruses representing six avian species and collected at different times during the outbreak revealed four different H5N1 genotypes. Most of the isolates possessed lysine at position 627 in the PB2 protein, a residue known to be associated with virulence in mice and adaptation to humans. However, neither of the two index viruses possessed this residue. All of the viruses tested were pathogenic in mice, with the exception of one index virus. We also tested the replication of two viruses isolated during the Qinghai Lake outbreak and one unrelated duck H5N1 virus in rhesus macaques. The Qinghai Lake viruses did not replicate efficiently in these animals, producing no evidence of disease other than transient fever, while the duck virus replicated in multiple organs and caused symptoms of respiratory illness. Importantly, H5N1 viruses isolated in Mongolia, Russia, Inner Mongolia, and the Liaoning Province of China after August 2005 were genetically closely related to one of the genotypes isolated during the Qinghai outbreak, suggesting the dominant nature of this genotype and underscoring the need for worldwide intensive surveillance to minimize its devastating consequences.
            Article 0 comments Cited 122 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Immunization by avian H5 influenza hemagglutinin mutants with altered receptor binding specificity.

              Zhi-Yong Yang, Chih-Jen Wei, Wing-Pui Kong … (2007)
              Influenza virus entry is mediated by the receptor binding domain (RBD) of its spike, the hemagglutinin (HA). Adaptation of avian viruses to humans is associated with HA specificity for alpha2,6- rather than alpha2,3-linked sialic acid (SA) receptors. Here, we define mutations in influenza A subtype H5N1 (avian) HA that alter its specificity for SA either by decreasing alpha2,3- or increasing alpha2,6-SA recognition. RBD mutants were used to develop vaccines and monoclonal antibodies that neutralized new variants. Structure-based modification of HA specificity can guide the development of preemptive vaccines and therapeutic monoclonal antibodies that can be evaluated before the emergence of human-adapted H5N1 strains.
              Article 0 comments Cited 100 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Emerg Infect Dis
                Journal ID (iso-abbrev): Emerg Infect Dis
                Journal ID (publisher-id): EID
                Title: Emerging Infectious Diseases
                Publisher: Centers for Disease Control and Prevention
                ISSN (Print): 1080-6040
                ISSN (Electronic): 1080-6059
                Publication date (Print): April 2021
                Volume: 27
                Issue: 4
                Pages: 1181-1183
                Affiliations
                [1]Konkuk University, Seoul, South Korea (S. Jeong, S.-H. Lee, A.Y. Cho, C.-S. Song);
                [2]Mongolian University of Life Sciences, Ulaanbaatar, Mongolia (N. Otgontogtokh, B. Davganyam, E.-O. Tseren-Ochir);
                [3]University of Connecticut, Storrs, Connecticut, USA (D.-H. Lee)
                Author notes
                Address for correspondence: Chang-Seon Song, College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, South Korea; e-mail: songcs@ 123456konkuk.ac.kr
                Article
                Publisher ID: 20-3859
                DOI: 10.3201/eid2704.203859
                PMC ID: 8007304
                PubMed ID: 33754986
                SO-VID: 6cd7dc7e-3160-4414-b928-ffa8b7ae1c5a
                History
                Categories
                Subject: Dispatch
                Subject: Dispatch
                Subject: Highly Pathogenic Avian Influenza Clade 2.3.4.4 Subtype H5N6 Viruses Isolated from Wild Whooper Swans, Mongolia, 2020

                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: influenza,zoonoses,viruses,mongolia,highly pathogenic avian influenza,wild whooper swans,h5n6,respiratory infections
                Data availability:
                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: influenza, zoonoses, viruses, mongolia, highly pathogenic avian influenza, wild whooper swans, h5n6, respiratory infections

                Comments

                Comment on this article

                scite_

                Similar content189

                See all similar

                Cited by5

                See all cited by

                Most referenced authors249

                See all reference authors