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      Glomerular Metabolism in Protein-Load Proteinuria


      S. Karger AG

      Protein-load, Proteinuria, Glomerulus, Metabolism, Rat

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          Rats were injected with various amounts of bovine albumin (0.5,1.0 and 1.75 g/24 h), inducing thereby proteinuria ranging from 100 to 400 mg/24 h. The glomerular oxygen uptake, dry weight and glucose-6-phosphate dehydrogenase (G-6-PDH) activity were measured on the 4th day of proteinuria and in a group of control animals. Oxygen uptake increased of +60%, expressed per glomerulus and of +25% when expressed per milligram dry weight and this increase was not different between the 3 groups of rats. Glomerular dry weight increased significantly in the 3 series. There was an highly significant relationship between glomerular dry weight and oxygen uptake, combining the 3 series together. G-6-PDH increased as expected from previous experiments and this increase was more marked for the more marked proteinuria. The relationship between G-6-PDH and QO<sub>2</sub> was of borderline statistical significance (p = 0.05). The glomerular hypertrophy, oxidative hyperactivity and increase in G-6-PDH activity are probably related to transcellular transport of protein.

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          Author and article information

          S. Karger AG
          02 December 2008
          : 19
          : 5
          : 259-264
          Laboratoire de Médecine Expérimentale, Université Libre de Bruxelles, Hôpital Brugmann, Bruxelles
          180898 Nephron 1977;19:259–264
          © 1977 S. Karger AG, Basel

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          Page count
          Pages: 6
          Original Paper

          Cardiovascular Medicine, Nephrology

          Rat, Metabolism, Glomerulus, Proteinuria, Protein-load


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