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      Estimation of toxic properties of nanocomposites containing nanoparticles of bismuth, gadolinium, and silver

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          Abstract

          Abstract. The aim of the study was to study the parameters of acute toxicity, gender effects, and activity of apoptosis modulator proteins bcl-2, caspase-3, and hsp70 in albino rat brain neurons in response to administration of silver, bismuth, gadolinium nanoparticles-containing nanocomposites. Parameters of acute toxicity of nanobiocomposites were determined by intragastric administration. Subacute toxicity was studied by intragastric administration of nanocomposites for 9 days at a rate of 500 µg/kg body weight. Immunohistochemical method was used for assessment of modulators of apoptosis of bcl-2 and caspase-3 in albino rat brain neurons and the activity of heat shock proteins. All nanobiocomposites belong to a low-hazard class of substances on the parameters of acute toxicity. At the same time, in a subacute experiment, despite the same matrix, the response of the organism was specific depending on the metal nanoparticles encapsulated in the matrix. Administration of silver nanocomposites caused proapoptotic effect in brain cells. Bismuth and gadolinium nanocomposites did not stimulate of programmed cell death in brain.


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          Characterization of silver nanoparticles synthesized by using marine isolate Streptomyces albidoflavus.

          Silver nanoparticles production by the green chemistry approach was investigated using an isolated marine actinomycetes strain. The isolated strain was identified as Streptomyces albidoflavus based on chemotaxonomic and ribotyping properties. The strain revealed production of silver nanoparticles both extracellular and intracellularly. Surface Plasmon Resonance analysis with the function of time revealed that particle synthesis by this strain is reaction time dependent. The produced particles were spherical shaped and monodispersive in nature and showed a single surface plasmon resonance peak at 410 nm. Size distribution histograms indicated production of 10-40- nm-size nanoparticles with a mean size of 14.5 nm. FT-IR spectra of nanopartilces showed N-H, C-H, and C-N stretching vibrations, denoting the presence of amino acid/ peptide compounds on the surface of silver nanoparticles produced by S. albidoflavus. Synthesized nanoparticles revealed a mean negative zeta potential and electrophoretic mobility of -8.5 mV and -0.000066 cm2/Vs, respectively. The nanoparticles produced were proteinaceous compounds as capping agents with -8.5 mV zeta potential and revealed antimicrobial activity against both Gram-negative and -positive bacterial strains. Owing to their small size, these particles have greater impact on industrial application spectra.
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            Ultrasensitive SERS-Based Immunoassay of Tumor Marker in Serum Using Au–Ag Alloy Nanoparticles and Ag/AgBr Hybrid Nanostructure

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              Larch arabinogalactan – properties and prospects.

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                Author and article information

                Journal
                Trace Elements and Electrolytes
                TE
                Dustri-Verlgag Dr. Karl Feistle
                0946-2104
                2018
                October 01 2018
                : 35
                : 10
                : 203-206
                Article
                10.5414/TEX0155408
                6d1ee218-0b02-45bd-bdc0-e063e928e6f9
                © 2018
                History

                Endocrinology & Diabetes,General medicine,Medicine,Gastroenterology & Hepatology,Nutrition & Dietetics
                apoptosis,toxicity,metal nanoparticles,rats

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