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      Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer

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          Abstract

          Background

          Obesity is a convincing risk factor for colorectal cancer. Genetic variants in or near FTO and MC4R are consistently associated with body mass index and other body size measures, but whether they are also associated with colorectal cancer risk is unclear.

          Methods

          In the discovery stage, we tested associations of 677 FTO and 323 MC4R single nucleotide polymorphisms (SNPs) 100kb upstream and 300kb downstream from each respective locus with risk of colorectal cancer in data from the Colon Cancer Family Registry (CCFR: 1,960 cases; 1,777 controls). Next, all SNPs that were nominally statistically signif icant (p<0.05) in the discovery stage were included in replication analyses in data from the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO: 9,716 cases; 9,844 controls).

          Results

          In the discovery stage, 43 FTO variants and 18 MC4R variants were associated with colorectal cancer risk (p<0.05). No SNPs remained statistically significant in the replication analysis after accounting for multiple comparisons.

          Conclusion

          We found no evidence that individual variants in or near the obesity-related genes FTO and MC4R are associated with risk of colorectal cancer.

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          Author and article information

          Journal
          101508793
          36207
          Cancer Epidemiol
          Cancer Epidemiol
          Cancer epidemiology
          1877-7821
          1877-783X
          29 October 2016
          21 July 2016
          October 2016
          01 October 2017
          : 44
          : 1-4
          Affiliations
          [1 ]Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA
          [2 ]Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA
          [3 ]Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA
          [4 ]Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
          [5 ]Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia
          [6 ]Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
          [7 ]Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA
          [8 ]Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
          [9 ]Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
          [10 ]German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
          [11 ]Division of Preventive Oncology and National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany
          [12 ]Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
          [13 ]Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
          [14 ]Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
          [15 ]Department of Medical Biophysics, University of Toronto, Toronto, Canada
          [16 ]Ontario Institute for Cancer Research, Toronto, Canada
          [17 ]Department of Molecular Genetics, University of Toronto, Toronto, Canada
          [18 ]Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA
          [19 ]Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA
          [20 ]Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA
          Author notes
          Correspondence to: Peter T. Campbell, Ph.D., Epidemiology Research Program, American Cancer Society National Home Office, 250 Williams Street NW, Atlanta, Georgia 30303. Peter.Campbell@ 123456cancer.org ; Tel: 404.327.6460; Fax: 404.327.6450
          [*]

          These two authors contributed equally to this work.

          Article
          PMC5125024 PMC5125024 5125024 nihpa807236
          10.1016/j.canep.2016.07.003
          5125024
          27449576
          6d2117ec-6079-4495-b899-7b5c48b60072
          History
          Categories
          Article

          obesity,case-control study,colorectal cancer,genetic variants

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