There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Thrombus formation is increased under conditions of hypoxia in animal models of thrombosis
and in human populations, but current therapies for thrombosis do not directly target
hypoxia-responsive signaling pathways. The vascular response to hypoxia is controlled
primarily by the hypoxia-inducible transcription factors (HIFs), whose target genes
include several factors that regulate thrombus formation. In this article, we review
the HIF-dependent and HIF-independent signaling pathways that regulate thrombus formation
under hypoxic conditions. A better understanding of hypoxia-induced thrombus formation
could lead to the development of novel prophylactic therapies for thrombosis.