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Induced pluripotent stem cells: a new revolution for clinical neurology?
Author(s):
Virginia B Mattis
,
Clive N Svendsen
Publication date
Created:
April 2011
Publication date
(Print):
April 2011
Journal:
The Lancet Neurology
Publisher:
Elsevier BV
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There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Why specific neuronal populations are uniquely susceptible in neurodegenerative diseases remains a mystery. Brain tissue samples from patients are rarely available for testing, and animal models frequently do not recapitulate all features of a specific disorder; therefore, pathophysiological investigations are difficult. An exciting new avenue for neurological research and drug development is the discovery that patients' somatic cells can be reprogrammed to a pluripotent state; these cells are known as induced pluripotent stem cells. Once pluripotency is reinstated, cell colonies can be expanded and differentiated into specific neural populations. The availability of these cells enables the monitoring in vitro of temporal features of disease initiation and progression, and testing of new drug treatments on the patient's own cells. Hence, this swiftly growing area of research has the potential to contribute greatly to our understanding of the pathophysiology of neurodegenerative and neurodevelopmental diseases. Copyright © 2011 Elsevier Ltd. All rights reserved.
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Stress signalling in stem cells
Author and article information
Journal
Title:
The Lancet Neurology
Abbreviated Title:
The Lancet Neurology
Publisher:
Elsevier BV
ISSN (Print):
14744422
Publication date Created:
April 2011
Publication date (Print):
April 2011
Volume
: 10
Issue
: 4
Pages
: 383-394
Article
DOI:
10.1016/S1474-4422(11)70022-9
PubMed ID:
21435601
SO-VID:
6d29029d-b92a-4d46-baca-74d0ce4db217
Copyright ©
© 2011
License:
https://www.elsevier.com/tdm/userlicense/1.0/
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