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      Quality of Life-a Goal for Schizophrenia’s Therapy

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          Abstract

          Quality of Life (QOL) assessment represents a good instrument to monitor the evolution of schizophrenia and the treatment’s outcomes. The present study has evaluated the relationship between the level of the QOL and different socio-demographical and clinical factors. Lower QOL for schizophrenic persons was influenced by the severity of symptoms and cognitive deficits, while same low level of QOL could be considered an indicator for suicidal behavior. The correct therapeutically management of individuals with schizophrenia could lead to better outcomes in terms of life satisfaction of patients and response to the treatment’s strategies.

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          The positive and negative syndrome scale (PANSS) for schizophrenia.

          L Opler, Jennifer Kay, Paul Opler … (1986)
          The variable results of positive-negative research with schizophrenics underscore the importance of well-characterized, standardized measurement techniques. We report on the development and initial standardization of the Positive and Negative Syndrome Scale (PANSS) for typological and dimensional assessment. Based on two established psychiatric rating systems, the 30-item PANSS was conceived as an operationalized, drug-sensitive instrument that provides balanced representation of positive and negative symptoms and gauges their relationship to one another and to global psychopathology. It thus constitutes four scales measuring positive and negative syndromes, their differential, and general severity of illness. Study of 101 schizophrenics found the four scales to be normally distributed and supported their reliability and stability. Positive and negative scores were inversely correlated once their common association with general psychopathology was extracted, suggesting that they represent mutually exclusive constructs. Review of five studies involving the PANSS provided evidence of its criterion-related validity with antecedent, genealogical, and concurrent measures, its predictive validity, its drug sensitivity, and its utility for both typological and dimensional assessment.
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            Psychiatric symptoms and quality of life in schizophrenia: a meta-analysis.

            Shaun Eack, Christina Newhill (2007)
            Quality of life (QoL) has been recognized as an important outcome of schizophrenia treatment, yet the determinants of QoL for individuals with schizophrenia are not well known. Research has consistently found psychiatric symptoms to be negatively related to QoL, however, findings concerning the strength of these relationships have been mixed, making it difficult to determine the degree to which such symptoms are related to poor QoL. This research presents a systematic meta-analysis of studies examining the relationship between psychiatric symptoms and QoL in schizophrenia, in an effort to elucidate the determinants of QoL for this population. A total of 56 studies were extracted from literature searches of relevant databases for empirical reports published between 1966 and 2005 examining the relationship between positive, negative, and/or general psychiatric symptoms and QoL. Weighted effect size analyses revealed small relationships between psychiatric symptoms and QoL, with general psychopathology showing the strongest negative associations across all QoL indicators. Moderator analyses indicated that variation in effect sizes could be accounted for by differing operationalizations of QoL, study design, sample, and participant treatment setting. In particular, positive and negative symptoms were more strongly related to poor QoL among studies of schizophrenia outpatients, whereas general psychopathology showed a consistent negative relationship with QoL across all study samples and treatment settings. Implications for future research and treatment development are discussed.
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              Development of the WHOQOL: Rationale and current status

              W Group, Group WHOQoL, WHOQOL The Group … (1994)
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                Author and article information

                Journal
                Journal ID (nlm-ta): Curr Health Sci J
                Journal ID (iso-abbrev): Curr Health Sci J
                Journal ID (publisher-id): CHSJ
                Title: Current Health Sciences Journal
                Publisher: Medical University Publishing House Craiova
                ISSN (Print): 2067-0656
                ISSN (Electronic): 2069-4032
                Publication date (Print): Apr-Jun 2018
                Publication date (Electronic): 27 March 2018
                Volume: 44
                Issue: 2
                Pages: 122-128
                Affiliations
                [1 ]University of Medicine and Pharmacy of Craiova, Faculty of Medicine, Craiova, Romania
                [2 ]Chronic Hospital of Psychiatry, Dumbrăveni, Romania
                [3 ]Lucian Blaga University Sibiu, Faculty of Medicine, Sibiu, Romania
                Author notes
                Corresponding Author: Lavinia Corina Duica, Lucian Blaga University Sibiu, Faculty of Medicine SibiuRomania laviniaduica@ 123456yahoo.com
                Article
                Publisher ID: 2018.02.05
                DOI: 10.12865/CHSJ.44.02.05
                PMC ID: 6320457
                PubMed ID: 30746158
                SO-VID: 6d340b52-6b2e-4e1d-9753-264791ebc279
                Copyright © Copyright © 2018, Medical University Publishing House Craiova
                License:

                This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.

                History
                Date received : 04 December 2017
                Date accepted : 27 March 2018
                Categories
                Subject: Original Paper

                Keywords: quality of life,schizophrenia,social adjustment,suicidal behavior
                Data availability:
                Keywords: quality of life, schizophrenia, social adjustment, suicidal behavior

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