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      Primary disruption of the default mode network subsystems in drug-naïve Parkinson's disease with mild cognitive impairments.

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          Abstract

          Mild cognitive impairment (MCI) in Parkinson's disease (PD) is related to the disrupted connectivity in networks involved in cognition, primarily in the default mode network (DMN). The DMN contains a midline core and two distinct subsystems (dorsal medial prefrontal cortex (DMPFC) and medial temporal lobe (MTL) subsystems).

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          Author and article information

          Journal
          Neuroradiology
          Neuroradiology
          Springer Science and Business Media LLC
          1432-1920
          0028-3940
          Jun 2020
          : 62
          : 6
          Affiliations
          [1 ] Department of neurology, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
          [2 ] Department of Radiology, Huaxi MR Research Center (HMRRC), West China Hospital, Sichuan University, Chengdu, Sichuan, China.
          [3 ] Department of neurology, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China. hfshang2002@126.com.
          Article
          10.1007/s00234-020-02378-z
          10.1007/s00234-020-02378-z
          32064569
          6d38ccd4-0265-4043-9879-3c7ae60f4150
          History

          Default mode network,Functional connectivity,Parkinson’s disease,Resting-state functional MRI,Subsystems

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