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Hypoxia-inducible factor 1: master regulator of O2 homeostasis
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Abstract
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates essential
homeostatic responses to reduced O2 availability in mammals. Recent studies have provided
insights into the O2-dependent regulation of HIF-1 expression, target genes regulated
by HIF-1, and the effects of HIF-1 deficiency on cellular physiology and embryonic
development.