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      Bufei Jianpi granules improve skeletal muscle and mitochondrial dysfunction in rats with chronic obstructive pulmonary disease.

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          Abstract

          Bufei Jianpi granules has been confirmed effective in improving pulmonary function, alleviating acute exacerbations, improving six-minute walk distance and quality of life, and benefited in 12-month follow-up in chronic obstructive pulmonary disease (COPD) patients with syndrome of lung-spleen qi deficiency. Skeletal muscle dysfunction (SMD), an important extrapulmonary complication, occurs in the very initiation of COPD and is closely related to morbidity and mortality. To evaluate the efficacy of Bufei Jianpi granules on SMD, we observed skeletal muscular function and histomorphology, mitochondrial morphormetry and proteins in COPD rats induced by cigarette-smoke and Klebsiella pneumoniae.

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          Author and article information

          Journal
          BMC Complement Altern Med
          BMC complementary and alternative medicine
          1472-6882
          1472-6882
          Mar 10 2015
          : 15
          Affiliations
          [1 ] Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China. docsxx@163.com.
          [2 ] Institute for Respiratory Diseases and the Level Three Laboratory of Respiration Pharmacology of TCM, the First Affiliated Hospital, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, 450000, China. docsxx@163.com.
          [3 ] Institute for Respiratory Diseases and the Level Three Laboratory of Respiration Pharmacology of TCM, the First Affiliated Hospital, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, 450000, China. yuanfengtcm@126.com.
          [4 ] Central Laboratory, the First Affiliated Hospital, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, 450000, China. yuanfengtcm@126.com.
          [5 ] Collaborative Innovation Center for Respiratory Diseases Diagnostics, Treatment and New Drug Research and Development in Henan Province, Zhengzhou, Henan, 450046, China. yuanfengtcm@126.com.
          [6 ] Institute for Respiratory Diseases and the Level Three Laboratory of Respiration Pharmacology of TCM, the First Affiliated Hospital, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, 450000, China. 563943153@qq.com.
          [7 ] Institute for Respiratory Diseases and the Level Three Laboratory of Respiration Pharmacology of TCM, the First Affiliated Hospital, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, 450000, China. 489432634@qq.com.
          [8 ] Institute for Respiratory Diseases and the Level Three Laboratory of Respiration Pharmacology of TCM, the First Affiliated Hospital, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, 450000, China. yaowsry@126.com.
          [9 ] Institute for Geriatrics, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, 450046, China. yange0910@126.com.
          [10 ] Institute for Respiratory Diseases and the Level Three Laboratory of Respiration Pharmacology of TCM, the First Affiliated Hospital, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, 450000, China. 742029370@qq.com.
          [11 ] Institute for Respiratory Diseases and the Level Three Laboratory of Respiration Pharmacology of TCM, the First Affiliated Hospital, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, 450000, China. 1042189907@qq.com.
          [12 ] Institute for Respiratory Diseases and the Level Three Laboratory of Respiration Pharmacology of TCM, the First Affiliated Hospital, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, 450000, China. lisuyun2000@126.com.
          [13 ] Collaborative Innovation Center for Respiratory Diseases Diagnostics, Treatment and New Drug Research and Development in Henan Province, Zhengzhou, Henan, 450046, China. lisuyun2000@126.com.
          [14 ] Institute for Geriatrics, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, 450046, China. lisuyun2000@126.com.
          [15 ] Institute for Respiratory Diseases and the Level Three Laboratory of Respiration Pharmacology of TCM, the First Affiliated Hospital, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, 450000, China. li_js8@163.com.
          [16 ] Collaborative Innovation Center for Respiratory Diseases Diagnostics, Treatment and New Drug Research and Development in Henan Province, Zhengzhou, Henan, 450046, China. li_js8@163.com.
          [17 ] Institute for Geriatrics, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, 450046, China. li_js8@163.com.
          Article
          10.1186/s12906-015-0559-x
          10.1186/s12906-015-0559-x
          4378020
          25888379
          6d3f9953-96ff-46e6-9b4c-3e6cc5e7321d
          History

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