5
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Hipervitaminosis A y lesiones hísticas hepáticas en ratas Sprague Dawley recién nacidas Translated title: Hypervitaminosis A and hepatic tissue lesions in newly born Sprague Dawley rats

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Related collections

          Most cited references10

          • Record: found
          • Abstract: not found
          • Article: not found

          Hepatic injury from chronic hypervitaminosis a resulting in portal hypertension and ascites.

            Bookmark
            • Record: found
            • Abstract: found
            • Article: found
            Is Open Access

            Vitamin A Oral Supplementation Induces Oxidative Stress and Suppresses IL-10 and HSP70 in Skeletal Muscle of Trained Rats

            Exercise training intensity is the major variant that influences the relationship between exercise, redox balance, and immune response. Supplement intake is a common practice for oxidative stress prevention; the effects of vitamin A (VA) on exercise training are not yet described, even though this molecule exhibits antioxidant properties. We investigated the role of VA supplementation on redox and immune responses of adult Wistar rats subjected to swimming training. Animals were divided into four groups: sedentary, sedentary + VA, exercise training, and exercise training + VA. Over eight weeks, animals were submitted to intense swimming 5 times/week and a VA daily intake of 450 retinol equivalents/day. VA impaired the total serum antioxidant capacity acquired by exercise, with no change in interleukin-1β and tumor necrosis factor-α levels. In skeletal muscle, VA caused lipid peroxidation and protein damage without differences in antioxidant enzyme activities; however, Western blot analysis showed that expression of superoxide dismutase-1 was downregulated, and upregulation of superoxide dismutase-2 induced by exercise was blunted by VA. Furthermore, VA supplementation decreased anti-inflammatory interleukin-10 and heat shock protein 70 expression, important factors for positive exercise adaptations and tissue damage prevention. Our data showed that VA supplementation did not confer any antioxidative and/or protective effects, attenuating exercise-acquired benefits in the skeletal muscle.
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Effects of vitamin A overdose on rat’s organs involved in immunity and vitamin A storage

                Bookmark

                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                rpr
                Revista de Ciencias Médicas de Pinar del Río
                Rev Ciencias Médicas
                Editorial Ciencias Médicas (Pinar del Río, , Cuba )
                1561-3194
                April 2018
                : 10-19
                Affiliations
                [01] Pinar del Río orgnameUniversidad de Ciencias Médicas de Pinar del Río. Cuba Cuba dunia@ 123456infomed.sld.cu
                Article
                S1561-31942018000200003
                6d69c50f-6b4c-4305-b35d-e3d4dda944a9

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 16 January 2018
                : 14 February 2018
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 15, Pages: 10
                Product

                SciELO Cuba


                HIPERVITAMINOSIS A,RATAS,HEPATOPATÍAS,HYPERVITAMINOSIS A,RATS,LIVER DISEASES

                Comments

                Comment on this article