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      Clinical Outcomes of Drug-Coated Balloon in Coronary Patients with and without Diabetes Mellitus: A Multicenter, Propensity Score Study

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          Abstract

          Background

          Relative to nondiabetic patients, percutaneous coronary intervention (PCI) in patients with diabetes mellitus (DM) is associated with inferior clinical outcomes. We aimed to evaluate the outcomes of drug-coated balloon (DCB) in diabetic versus nondiabetic patients.

          Methods and Results

          In this observational, prospective, multicenter study, we compared the outcomes of patients with and without DM after undergoing PCI with DCBs. Target lesion failure (TLF) was analyzed as primary endpoint. Secondary endpoints were the rates of target lesion revascularization (TLR), major adverse cardiovascular events (MACE), cardiac death, myocardial infarction (MI), and any revascularization. Propensity score matching was used to assemble a cohort of patients with similar baseline characteristics. Among 2,306 eligible patients, 578 with DM and 578 without DM had similar propensity scores and were included in the analyses. During follow-up (366 ± 46 days), compared with DM patients, patients without DM were associated with a lower yearly incidence of TLF (2.77% vs. 5.36%; OR, 1.991; 95% CI, 1.077 to 3.681; P = 0.025) and TLR (1.90% vs. 4.15%; OR, 2.233; 95% CI, 1.083 to 4.602; P = 0.026). No significant differences were observed with regards to rates of MACE (OR: 1.580, 95% CI: 0.912-2.735; P = 0.100), cardiac death (OR: 1.608, 95% CI: 0.523-4.946; P = 0.403), MI (OR: 4.042, 95% CI: 0.855-19.117; P = 0.057), and any revascularization (OR: 1.534, 95% CI: 0.983-2.393; P = 0.058).

          Conclusions

          Diabetic patients experience higher TLF and TLR rates following DCB angioplasty without substantial increase in the risk of MACE, cardiac death, MI, or revascularization.

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          Most cited references31

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          2018 ESC/EACTS Guidelines on myocardial revascularization

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            Fourth Universal Definition of Myocardial Infarction (2018)

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              2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS

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                Author and article information

                Contributors
                Journal
                J Diabetes Res
                J Diabetes Res
                JDR
                Journal of Diabetes Research
                Hindawi
                2314-6745
                2314-6753
                2021
                29 July 2021
                : 2021
                : 5495219
                Affiliations
                1Department of Cardiovascular Medicine, The First Affiliated Hospital of Zhengzhou University, China
                2Department of Cardiovascular Medicine, Jincheng People's Hospital, China
                3Department of Geriatric Cardiology, The First Affiliated Hospital of Zhengzhou University, China
                4Department of Cardiology, The Fifth Affiliated Hospital of Zhengzhou University, China
                Author notes

                Academic Editor: Raffaele Marfella

                Author information
                https://orcid.org/0000-0002-7859-8319
                https://orcid.org/0000-0001-8618-4477
                https://orcid.org/0000-0001-8547-2557
                https://orcid.org/0000-0002-5195-3691
                https://orcid.org/0000-0003-2310-6759
                https://orcid.org/0000-0002-5785-191X
                https://orcid.org/0000-0003-2877-2582
                https://orcid.org/0000-0003-1974-3149
                https://orcid.org/0000-0003-0346-9579
                https://orcid.org/0000-0002-7026-8104
                https://orcid.org/0000-0003-4046-1146
                https://orcid.org/0000-0002-9171-2745
                https://orcid.org/0000-0001-5067-4140
                https://orcid.org/0000-0001-8452-3084
                https://orcid.org/0000-0003-0818-8610
                Article
                10.1155/2021/5495219
                8342102
                34368364
                6d71e484-edfe-4f4f-b252-ba00f47a0c21
                Copyright © 2021 Liang Pan et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 8 June 2021
                : 15 July 2021
                Funding
                Funded by: Medical Science and Technique Research Plan of Henan Province
                Award ID: SB201901027
                Categories
                Research Article

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