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      Genetic features of the widespread plasmid coding for the carbapenemase OXA-48.

      Antimicrobial Agents and Chemotherapy
      Africa, Northern, epidemiology, Anti-Bacterial Agents, therapeutic use, Bacterial Proteins, chemistry, genetics, metabolism, Bacterial Typing Techniques, Base Sequence, Carbapenems, DNA Transposable Elements, DNA, Bacterial, Europe, Humans, Klebsiella Infections, drug therapy, microbiology, Klebsiella pneumoniae, enzymology, Microbial Sensitivity Tests, Middle East, Molecular Sequence Data, Plasmids, beta-Lactam Resistance, beta-Lactamases

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          Abstract

          Complete sequencing of plasmid pOXA-48a carrying the bla(OXA-48) gene from a Klebsiella pneumoniae isolate was performed. Its backbone corresponded to that of an IncL/M-type plasmid, in which the bla(OXA-48) gene had been integrated through the acquisition of the Tn1999 composite transposon without any other antibiotic resistance gene. Molecular epidemiology using a collection of international OXA-48 producers revealed the wide diffusion of pOXA-48a or closely related plasmids.

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