7
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Novel short antimicrobial peptide isolated from Xenopus laevis skin.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          A rich source of bioactive peptides, including a large number of antimicrobial peptides, has been found in amphibian skin. In this study, a novel short antimicrobial peptide was purified from Xenopus laevis skin and characterised through reversed-phase high-performance liquid chromatography, Edman degradation and matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry. The peptide was composed of six amino acids with a sequence of DEDLDE and thus named X. laevis antibacterial peptide-P2 (XLAsp-P2). Transmission electron microscopy revealed that this peptide showed potential antimicrobial abilities against bacteria by damaging the bacterial cell membrane. XLAsp-P2 maybe inhibit bacterial growth by binding to the microbial genomic DNA. The peptide also exhibited a weak haemolytic activity against rabbit red blood cells. Therefore, XLAsp-P2 is a novel short anionic antibacterial peptide with broad activities. Copyright © 2017 European Peptide Society and John Wiley & Sons, Ltd.

          Related collections

          Author and article information

          Journal
          J. Pept. Sci.
          Journal of peptide science : an official publication of the European Peptide Society
          Wiley-Blackwell
          1099-1387
          1075-2617
          May 2017
          : 23
          : 5
          Affiliations
          [1 ] College of Animal Science, Jilin University, Changchun, Jilin Province, 130062, China.
          [2 ] Five-Star Animal Health Pharmaceutical Factory of Jilin Province, Changchun, Jilin Province, 130062, China.
          [3 ] China National Corp of Traditional and Herbal Medicine Changbaishan Co. Ltd., Yanji, Jilin Province, 133000, China.
          [4 ] IACA Biological Technology Co. Ltd., Tianjin, 300475, China.
          Article
          10.1002/psc.2990
          28299865
          6d818d9d-cc4b-45fe-ae02-7d327da46176
          History

          Xenopus laevis,antimicrobial characterisation,antimicrobial peptides,cell haemolysis

          Comments

          Comment on this article