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      Sublingual versus oral misoprostol for uterine evacuation following early pregnancy failure.

      International Journal of Gynaecology and Obstetrics
      Abortifacient Agents, Nonsteroidal, administration & dosage, adverse effects, therapeutic use, Abortion, Incomplete, drug therapy, Administration, Oral, Administration, Sublingual, Adult, Female, Humans, Misoprostol, Pregnancy, Time Factors, Treatment Outcome, Young Adult

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          Abstract

          To compare the efficacy of misoprostol administered sublingually or orally for uterine evacuation after early pregnancy failure. Forty-eight hours after receiving 200 mg of mifepristone orally, 100 women were randomized to receive misoprostol sublingually or orally. The evacuation rates were 92% in the sublingual and 84% in the oral administration group; the mean+/-SD induction-to-evacuation intervals were 5.6+/-4.54 hours and 9.44+/-5.61 hours, this difference being significant; and the adverse effects were similar in the 2 groups. The sublingual route was found to be as effective but faster than the oral route for uterine evacuation after early pregnancy failure.

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