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Myocardial mapping of T1 and T2 with 3D-QALAS - precision of independent and dependent scans in healthy subjects

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Journal of Cardiovascular Magnetic Resonance

BioMed Central

19th Annual SCMR Scientific Sessions

27-30 January 2016

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      Simultaneous three-dimensional myocardial T1 and T2 mapping in one breath hold with 3D-QALAS

      Background Quantification of the longitudinal- and transverse relaxation time in the myocardium has shown to provide important information in cardiac diagnostics. Methods for cardiac relaxation time mapping generally demand a long breath hold to measure either T1 or T2 in a single 2D slice. In this paper we present and evaluate a novel method for 3D interleaved T1 and T2 mapping of the whole left ventricular myocardium within a single breath hold of 15 heartbeats. Methods The 3D-QALAS (3D-quantification using an interleaved Look-Locker acquisition sequence with T2 preparation pulse) is based on a 3D spoiled Turbo Field Echo sequence using inversion recovery with interleaved T2 preparation. Quantification of both T1 and T2 in a volume of 13 slices with a resolution of 2.0x2.0x6.0 mm is obtained from five measurements by using simulations of the longitudinal magnetizations Mz. This acquisition scheme is repeated three times to sample k-space. The method was evaluated both in-vitro (validated against Inversion Recovery and Multi Echo) and in-vivo (validated against MOLLI and Dual Echo). Results In-vitro, a strong relation was found between 3D-QALAS and Inversion Recovery (R = 0.998; N = 10; p < 0.01) and between 3D-QALAS and Multi Echo (R = 0.996; N = 10; p < 0.01). The 3D-QALAS method showed no dependence on e.g. heart rate in the interval of 40–120 bpm. In healthy myocardium, the mean T1 value was 1083 ± 43 ms (mean ± SD) for 3D-QALAS and 1089 ± 54 ms for MOLLI, while the mean T2 value was 50.4 ± 3.6 ms 3D-QALAS and 50.3 ± 3.5 ms for Dual Echo. No significant difference in in-vivo relaxation times was found between 3D-QALAS and MOLLI (N = 10; p = 0.65) respectively 3D-QALAS and Dual Echo (N = 10; p = 0.925) for the ten healthy volunteers. Conclusions The 3D-QALAS method has demonstrated good accuracy and intra-scan variability both in-vitro and in-vivo. It allows rapid acquisition and provides quantitative information of both T1 and T2 relaxation times in the same scan with full coverage of the left ventricle, enabling clinical application in a broader spectrum of cardiac disorders.
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        Author and article information

        Affiliations
        [1 ]Institution for Medicine and Health Science, Linköping, Sweden
        [2 ]Center for Medical Image Science and Visualization (CMIV), Linköping, Sweden
        Conference
        J Cardiovasc Magn Reson
        J Cardiovasc Magn Reson
        Journal of Cardiovascular Magnetic Resonance
        BioMed Central (London )
        1097-6647
        1532-429X
        27 January 2016
        27 January 2016
        2016
        : 18
        Issue : Suppl 1 Issue sponsor : Publication of this supplement was funded by the Society for Cardiovascular Magnetic Resonance.
        5032074
        4935
        10.1186/1532-429X-18-S1-P11
        © Kvernby et al. 2016

        This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

        19th Annual SCMR Scientific Sessions
        Los Angeles, CA, USA
        27-30 January 2016
        Categories
        Poster Presentation
        Custom metadata
        © The Author(s) 2016

        Cardiovascular Medicine

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