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      Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems.

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          Abstract

          Specific sigma binding sites have been identified in the mammalian brain and lymphoid tissue. In this study, certain gonadal and adrenal steroids, particularly progesterone, were found to inhibit sigma receptor binding in homogenates of brain and spleen. The findings suggest that steroids are naturally occurring ligands for sigma receptors and raise the possibility that these sites mediate some aspects of steroid-induced mental disturbances and alterations in immune functions.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          0036-8075
          0036-8075
          Apr 08 1988
          : 240
          : 4849
          Affiliations
          [1 ] Addiction Research Center, National Institute on Drug Abuse, Baltimore, MD 21224.
          Article
          10.1126/science.2832949
          2832949
          6da59c05-faec-4ee0-97e4-2072fa3fe1c8
          History

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