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      Isosorbide 5-Mononitrate Pharmacokinetics

      Cardiology

      S. Karger AG

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          Abstract

          Isosorbide 5-mononitrate differs from other clinically used organic nitrate vasodilators because of its almost complete oral absorption, the low intersubject variability in its plasma concentrations and pharmacokinetic parameters, its relatively long half-life and its lack of active metabolites. The drug does not appear to be bound to plasma proteins and it is metabolized primarily by denitration and conjugation. Its clearance is 127 ml/min, volume of distribution 48.5 litres and half-life 4.4 h. Its pharmacokinetics are linear over the dosage range likely to be used clinically. Sustained-release formulations of the drug could prove suitable for once-a-day administration. In disease states (cardiac, renal or hepatic), the plasma concentrations and pharmacokinetics of the drug appear to be similar to those in healthy subjects.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          978-3-8055-4626-3
          978-3-318-01758-8
          0008-6312
          1421-9751
          1987
          1987
          11 November 2008
          : 74
          : Suppl 1
          : 6-11
          Affiliations
          Department of Metabolism and Pharmacokinetics, Huntingdon Research Centre, Huntingdon, Cambs., UK
          Article
          174255 Cardiology 1987;74:6–11
          10.1159/000174255
          3300979
          © 1987 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Paper

          General medicine, Neurology, Cardiovascular Medicine, Internal medicine, Nephrology

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