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      TOR signaling in growth and metabolism.

      1 , ,
      Cell
      Elsevier BV

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          Abstract

          The target of rapamycin (TOR) is a conserved Ser/Thr kinase that regulates cell growth and metabolism in response to environmental cues. Here, highlighting contributions from studies in model organisms, we review mammalian TOR complexes and the signaling branches they mediate. TOR is part of two distinct multiprotein complexes, TOR complex 1 (TORC1), which is sensitive to rapamycin, and TORC2, which is not. The physiological consequences of mammalian TORC1 dysregulation suggest that inhibitors of mammalian TOR may be useful in the treatment of cancer, cardiovascular disease, autoimmunity, and metabolic disorders.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          0092-8674
          0092-8674
          Feb 10 2006
          : 124
          : 3
          Affiliations
          [1 ] Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.
          Article
          S0092-8674(06)00108-5
          10.1016/j.cell.2006.01.016
          16469695
          6db67aab-e349-4cb8-8c59-0ddaafa630c5
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