Comparative analysis of elemental status in benign and malignant brain tumors

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Abstract

Abstract. The parameters of mineral metabolism in blood plasma and tumor tissue were analyzed in 12 patients with malignant and 7 patients with benign brain tumors before treatment. As a control, the brain tissue was used from the corpses of 7 people who died as a result of trauma and blood from 10 practically healthy people. The level of macroelements and trace elements was evaluated by atomic-emission spectrometry. A statistically significant increase in the concentration of Ca, Na and a decrease in Mg, K, P in tumor tissue of the brain was revealed in comparison with the brain tissue of the control group and patients with benign tumors. The level of trace elements in the tumor tissue also changed: the content of Fe, Zn, Cu, Se, Li, and Sr increased by a factor of 3.5, 2.9, 4.3, 2.3, 2.4, and 5, respectively. When analyzing the element levels of blood plasma, there was no significant change in the Na level; the content of K, Ca, Mg, and P increased in comparison with the results of the control group by a factor of 2.3, 1.3, 16, and 3.14, respectively. In the blood plasma, the content of Fe, Zn, Li, and Sr also increased by a factor of 2, 2.1, 2.7, and 4, respectively, and Cu and Se, on the contrary, decreased by a factor of 1.7 and 1.8. 

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Characterization of silver nanoparticles synthesized by using marine isolate Streptomyces albidoflavus.

Girija Shankar Guntuku, Sudheer Kumar Yannam, Reddy Shetty Prakasham … (2012)

Silver nanoparticles production by the green chemistry approach was investigated using an isolated marine actinomycetes strain. The isolated strain was identified as Streptomyces albidoflavus based on chemotaxonomic and ribotyping properties. The strain revealed production of silver nanoparticles both extracellular and intracellularly. Surface Plasmon Resonance analysis with the function of time revealed that particle synthesis by this strain is reaction time dependent. The produced particles were spherical shaped and monodispersive in nature and showed a single surface plasmon resonance peak at 410 nm. Size distribution histograms indicated production of 10-40- nm-size nanoparticles with a mean size of 14.5 nm. FT-IR spectra of nanopartilces showed N-H, C-H, and C-N stretching vibrations, denoting the presence of amino acid/ peptide compounds on the surface of silver nanoparticles produced by S. albidoflavus. Synthesized nanoparticles revealed a mean negative zeta potential and electrophoretic mobility of -8.5 mV and -0.000066 cm2/Vs, respectively. The nanoparticles produced were proteinaceous compounds as capping agents with -8.5 mV zeta potential and revealed antimicrobial activity against both Gram-negative and -positive bacterial strains. Owing to their small size, these particles have greater impact on industrial application spectra.